规格

价格

库存

数量

20 μg

¥ 5,930

35日内发货

生物活性

产品描述	CDK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q14004.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
研究背景	cyclin-dependent kinase 12 (CDK12) and 13 evolved by duplication of a common gene ancestor, a single paralog being found in non-vertebrates deuterostomes. In mammalian cells, both kinases operate in separate complexes, which could have different functions. CDK13 is localised in the nucleus and particularly in speckles, the storage site for splicing factors. CDK13 plays a role in splicing regulation by controlling the phosphorylation status and the activity of splicing factors. CDK13 interacts with p32 a protein associating with the splicing factor SRSF1 (also known as ASF/SF2). Through its association with p32 and by phosphorylating SRSF1, CDK13 increases the mRNA splicing of human immunodeficient virus type 1 (HIV-1) and its overexpression, suppresses virus production.
种属	Human
表达系统	Baculovirus-Insect Cells
标签	N-GST
蛋白编号	Q14004
蛋白构建	Recombinant human CDK13 (516-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
蛋白纯度	>70% as determined by SDS-PAGE.
蛋白性状	Solution
缓冲液	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
别名	KIAA1791, hCDK13, Cyclin-dependent kinase 13, CHED, CDK13, CDC2L5, CDC2L

化学信息

分子量

~160 kDa

储存&溶解度

运输方式

Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.

存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

CDK13 Protein, Human, Recombinant (GST)

CDK13 Protein, Human, Recombinant (GST)

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