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ANG2 Protein, Mouse, Recombinant (hFc)

ANG2 Protein, Mouse, Recombinant (hFc)

产品编号 TMPJ-00303
别名: angiopoietin 2, Angiopoietin-2, ANG2, angiopoitin 2, Tie2-ligand, 血管生成素, ANG-2, angiopoietin-2B, angiopoietin-2a, AGPT2, ANGPT2

ANG2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is O35608.

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ANG2 Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 580 5日内发货
50 μg ¥ 1,770 5日内发货
500 μg ¥ 13,300 5日内发货
1 mg ¥ 20,000 5日内发货
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产品目录号及名称: ANG2 Protein, Mouse, Recombinant (hFc) (TMPJ-00303)
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产品描述 ANG2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is O35608.
种属 Mouse
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 O35608
别名 angiopoietin 2, Angiopoietin-2, ANG2, angiopoitin 2, Tie2-ligand, 血管生成素, ANG-2, angiopoietin-2B, angiopoietin-2a, AGPT2, ANGPT2
氨基酸序列 Tyr19-Phe496
蛋白构建 Tyr19-Phe496
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 90-120 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

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Keywords

ANG2 Protein, Mouse, Recombinant (hFc) angiopoietin 2 Angiopoietin-2 ANG2 angiopoitin 2 Tie2-ligand 血管生成素 ANG-2 AGPT 2 ANGPT-2 angiopoietin-2B AGPT-2 angiopoietin-2a AGPT2 ANGPT 2 ANGPT2 ANG 2 recombinant recombinant-proteins proteins protein

 

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