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ALDH4A1 Protein, Human, Recombinant

产品编号 TMPY-03433

别名: aldehyde dehydrogenase 4 family, member A1, P5CD, P5CDh, ALDH4

ALDH4A1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 59.2 kDa and the accession number is AAH07581.1.

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ALDH4A1 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 5,100		5日内发货

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生物活性	Testing in progress
产品描述	ALDH4A1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 59.2 kDa and the accession number is AAH07581.1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	AAH07581.1
别名	aldehyde dehydrogenase 4 family, member A1, P5CD, P5CDh, ALDH4
蛋白构建	The Human ALDH4A1 (AAH07581.1) (Lys 25-Gln 563) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	59.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.

参考文献

1. Goodman SI, et al. (1974) Defective hydroxyproline metabolism in type II hyperprolinemia. Biochemical medicine. 10 (4): 329-36. 2. Maruyama K, et al. (1994) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138 (1-2): 171-4. 3. Vasiliou V, et al. (2005) Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics. 2 (2): 138-43.

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Keywords

ALDH4A1 Protein, Human, Recombinant ALDH 4 aldehyde dehydrogenase 4 family, member A1 P5CD ALDH-4 P5CDh ALDH4 recombinant recombinant-proteins proteins protein

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