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Morpholinylmercaptobenzothiazole
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很棒纯度: 95%
货号 T9046Cas号 102-77-2
Morpholinylmercaptobenzothiazole 是一种后效快速硫化促进剂。
Morpholinylmercaptobenzothiazole
一键复制产品信息 很棒纯度: 95%
货号 T9046Cas号 102-77-2
Morpholinylmercaptobenzothiazole 是一种后效快速硫化促进剂。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 g | ¥ 99 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 99 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍
Morpholinylmercaptobenzothiazole AI Summary
Morpholinylmercaptobenzothiazole demonstrates a wide range of bioactivities, exhibiting both broad-spectrum and specific inhibitory effects across various biological targets and pathways. It shows significant potency in inhibiting enzymes and proteins such as HSD17B4, JMJD2E, Muscle Pyruvate Kinase, Aldehyde Dehydrogenase 1, 15-hLO, HPGD, GCN5L2, Histone Lysine Methyltransferase G9a, and ROR gamma transcriptional activity. Additionally, it interacts with the JMJD2A-Tudor Domain, 15-hLO-2, Vitamin D Receptor, HP1-beta Chromodomain, selenoprotein Thioredoxin Reductase 1 (TrxR1), TGF-b, Regulator of G Protein Signaling (RGS) 4, TDP1, PLK1-PDB, Trypanosoma brucei, and inhibits the entry of Ebola Virus.
The compound exhibits varying potencies in different assays, indicating multiple target interactions with different affinities. Specifically, it shows notable antiviral activities: it reduces SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 47.0% at 10 µM concentration after 48 hours and achieves 99.31% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. It also inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 µM with an inhibition percentage of 0.14%.
Furthermore, Morpholinylmercaptobenzothiazole inhibits human HDAC6 enzyme activities significantly, with inhibition percentages of 58.19% and 15.97% in assays conducted with commercial and custom peptide substrates, respectively. This suggests its potential in epigenetic regulation and related therapeutic applications. Overall, Morpholinylmercaptobenzothiazole's diverse bioactivities make it a versatile candidate for therapeutic research and drug development..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Morpholinylmercaptobenzothiazole is an aftereffect rapid vulcanization accelerator |
| 分子量 | 252.36 |
| 分子式 | C11H12N2OS2 |
| CAS No. | 102-77-2 |
| Smiles | C1CN(CCO1)Sc1nc2ccccc2s1 |
| 密度 | 1.37 g/cm3. |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | DMSO: 10 mg/mL (39.63 mM), Sonication is recommended.  | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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