MDTF free acid serves as a non-cleavable ADC linker, utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

MDTF free acid (50 μM) enhances hydrophilic properties by substituting a cyclohexyl ring, and a MD-based FRET probe incubated in human plasma demonstrates a significantly higher self-stabilization rate than the MCC-based probe [1].