Name: BI-1206
Brand: TargetMol
SKU: T9901A-951
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	BI-1206 represents a highly specialized antagonistic monoclonal antibody specifically engineered to target the human inhibitory Fc gamma receptor IIB with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of receptor-mediated internalization of therapeutic antibodies across various preclinical experimental models to evaluate the enhancement of antibody-dependent cellular cytotoxicity in specialized oncology research environments.
体外活性	在利用地幔细胞淋巴瘤细胞系进行的 ADCP 和 ADCC 实验中，BI-1206 阻断了由 FcgammaRIIB 介导的利妥昔单抗内吞，从而增强了效应细胞介导的肿瘤细胞杀伤 [1]。
体内活性	在人淋巴瘤异种移植模型中，通过全身给药方式给予 BI-1206 联用利妥昔单抗导致了强效的肿瘤退缩并显著改善了生存期 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P31994
靶点	Fc-gamma-RIIB/CD32b

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

BI-1206