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Anti-IL13 Monoclonal Antibody-Biotin

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产品编号 TMAZ-0022B

别名 Interleukin-13

Anti-IL13 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。

Anti-IL13 Monoclonal Antibody-Biotin

Anti-IL13 Monoclonal Antibody-Biotin

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Rating icon 还可以
产品编号 TMAZ-0022B 别名 Interleukin-13

Anti-IL13 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。

规格价格库存数量
25 μg
¥ 2,620
7日内发货
50 μg
¥ 3,143
7日内发货
100 μg
¥ 4,400
7日内发货
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产品介绍

生物活性
产品描述
Anti-IL13 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting IL13. Anti-IL13 Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF.
别名Interleukin-13
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of IL13 overexpressed 382F cells with TMAZ-0022B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用ELISAFCMIF
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL13 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed: 8096327, PubMed: 8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed: 8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed: 7903680, PubMed: 8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed: 8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed: 9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed: 21622864)
偶联与修饰
偶联
Biotin
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
IL13
抗原种属
Human
基因ID
3596
Uniprot ID
P35225
研究领域
Immunology Research
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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