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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-USP5 Antibody (5C807)

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货号 TMAB-14027

Anti-USP5 Antibody (5C807) 是一种 Mouse 抗体，靶向 USP5。Anti-USP5 Antibody (5C807) 可用于 WB。

Anti-USP5 Antibody (5C807)

Anti-USP5 Antibody (5C807)

一键复制产品信息
Rating icon 还可以
货号 TMAB-14027

Anti-USP5 Antibody (5C807) 是一种 Mouse 抗体，靶向 USP5。Anti-USP5 Antibody (5C807) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
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产品介绍

生物活性
产品描述
Anti-USP5 Antibody (5C807) is a Mouse antibody targeting USP5. Anti-USP5 Antibody (5C807) can be used in WB.
Ig Type
IgG1, k
克隆号
5C807
反应种属
Human,Mouse,Rat
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Profound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence specific transcription factors. Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
抗原信息
免疫原
Recombinant Protein: human USP5
抗原种属
Human
基因名称
USP5
基因ID
8078
蛋白名称
Ubiquitin specific peptidase 5
Uniprot ID
P45974
功能
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
化学信息
分子量Theoretical: 96 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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