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Anti-Urokinase/uPA Antibody-HRP (4H675)
还可以产品编号 TMAY-01201H
Anti-Urokinase/uPA Antibody-HRP (4H675) 是一种 HRP-conjugated Mouse 抗体，靶向 Urokinase/uPA。Anti-Urokinase/uPA Antibody-HRP (4H675) 可用于 ELISA。
Anti-Urokinase/uPA Antibody-HRP (4H675)
Anti-Urokinase/uPA Antibody-HRP (4H675)
还可以产品编号 TMAY-01201H
Anti-Urokinase/uPA Antibody-HRP (4H675) 是一种 HRP-conjugated Mouse 抗体，靶向 Urokinase/uPA。Anti-Urokinase/uPA Antibody-HRP (4H675) 可用于 ELISA。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Urokinase/uPA Antibody-HRP (4H675) is a HRP-conjugated Mouse antibody targeting Urokinase/uPA. Anti-Urokinase/uPA Antibody-HRP (4H675) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4H675 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Urokinase / PLAU (rh Urokinase / PLAU; TMPY-00904; NP_002649.1; Met1-Leu431). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodelling, pro-hormone conversion, carcinogenesis and neoplasia. Like many components of the blood coagulation, fibrinolytic and complement cascades, uPA has a modular structure, including three conserved domains: a growth factor-like domain (GFD, residues 1-49), a kringle domain (residues 50-131), linked by an interdomain linker or "connecting peptide" (CP, residues 132-158) to the serine protease domain (residues 159-411). uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). The role of uPA is not only linked to its action as an enzyme. In fact, the mere binding of uPA on the cell surface also brings about two events that broaden the spectrum of its biological functions: (1) a conformational change of the receptor, which, in turn, affects its interaction with other proteins; (2) a signal transduction which modulates the expression of apoptosis-related genes. Besides its applications as a thrombolytic agent and as a prognostic marker for tumors, uPA may provide the basis for other therapies, as the structure of the receptor-binding domain of uPA has become a model for the design of anti-cancer molecules. Because of the causal involvment of uPA in cancer invasion and metastasis, the blockade of uPA interactions and activity with specific inhibitors is of interest for novel strategies in cancer therapy. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human Urokinase / PLAU Protein (TMPY-00904) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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