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Anti-TREM-1 Antibody-PE (8K185)
还可以产品编号 TMAY-00920P
Anti-TREM-1 Antibody-PE (8K185) 是一种 PE-conjugated Mouse 抗体，靶向 TREM-1。Anti-TREM-1 Antibody-PE (8K185) 可用于 FCM。
Anti-TREM-1 Antibody-PE (8K185)
Anti-TREM-1 Antibody-PE (8K185)
还可以产品编号 TMAY-00920P
Anti-TREM-1 Antibody-PE (8K185) 是一种 PE-conjugated Mouse 抗体，靶向 TREM-1。Anti-TREM-1 Antibody-PE (8K185) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-TREM-1 Antibody-PE (8K185) is a PE-conjugated Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody-PE (8K185) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 8K185 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human TREM-1(CD354) expression on human whole blood granulocytes. Cells were stained with PE-conjugated anti-Human TREM-1(CD354). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-1 / TREM1 (rh TREM-1 / TREM1; TMPY-00943; NP_061113.1; Met1-Arg200) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human TREM-1 / TREM1 Protein (TMPY-00943) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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