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Anti-Tissue Factor Antibody-FITC (2C735)
还可以产品编号 TMAY-02497F
Anti-Tissue Factor Antibody-FITC (2C735) 是一种 FITC-conjugated Mouse 抗体，靶向 Tissue Factor。Anti-Tissue Factor Antibody-FITC (2C735) 可用于 FCM。
Anti-Tissue Factor Antibody-FITC (2C735)
Anti-Tissue Factor Antibody-FITC (2C735)
还可以产品编号 TMAY-02497F
Anti-Tissue Factor Antibody-FITC (2C735) 是一种 FITC-conjugated Mouse 抗体，靶向 Tissue Factor。Anti-Tissue Factor Antibody-FITC (2C735) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Tissue Factor Antibody-FITC (2C735) is a FITC-conjugated Mouse antibody targeting Tissue Factor. Anti-Tissue Factor Antibody-FITC (2C735) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 2C735 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of F3 (CD142) expression on human A431 cells. |
| 应用 | FCM |
| 推荐剂量 | 1 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human F3 / Tissue factor / CD142 (rh F3 / Tissue factor / CD142; TMPY-02530; P13726; Met 1-Glu 251) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/APC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human F3 / Tissue factor / CD142 protein (TMPY-02530) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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