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Anti-Synapsin III Polyclonal Antibody

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货号 TMAB-13309

Anti-Synapsin III Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Synapsin III。Anti-Synapsin III Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Synapsin III Polyclonal Antibody

Anti-Synapsin III Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-13309

Anti-Synapsin III Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Synapsin III。Anti-Synapsin III Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-Synapsin III Polyclonal Antibody is a Rabbit antibody targeting Synapsin III. Anti-Synapsin III Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
组织特异性Neuron specific. Detected predominantly in brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Synapsin III
抗原种属
Human
基因名称
SYN3
基因ID
8224
蛋白名称
Synapsin-3
Uniprot ID
O14994
功能
Synapsin III may be involved in the regulation of neurotransmitter release and synaptogenesis. It shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. Synapsin III contains a unique domain, J, located between domains C and E. Based on the Synapsin III gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction.
化学信息
分子量Theoretical: 63 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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