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Anti-SIRP alpha Antibody-PE (8I335) 是一种 PE-conjugated Mouse 抗体，靶向 SIRP alpha。Anti-SIRP alpha Antibody-PE (8I335) 可用于 FCM。
还可以Anti-SIRP alpha Antibody-PE (8I335) 是一种 PE-conjugated Mouse 抗体，靶向 SIRP alpha。Anti-SIRP alpha Antibody-PE (8I335) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 T | ¥ 685 | 5日内发货 | |
| 100 T | ¥ 2,195 | 5日内发货 |
| 产品描述 | Anti-SIRP alpha Antibody-PE (8I335) is a PE-conjugated Mouse antibody targeting SIRP alpha. Anti-SIRP alpha Antibody-PE (8I335) can be used in FCM. |
| 别名 | SIRP α, SIRP alpha, SIRP, signal-regulatory protein α, signal-regulatory protein alpha, SHPS1, PTPNS1, P84, MYD-1, MFR, CD172A, BIT |
| Ig Type | Mouse IgG2b |
| 克隆号 | 8I335 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of anti-human SIRPa (CD172a) on human whole blood monocytes. Human monocytess were stained with PE-anti human SIRPa (CD172a) (solid line) or PE-Mouse isotype control (dashed line). |
| 应用 | |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SIRPA / CD172A (rh SIRPA / CD172A; TMPY-01573; NP_542970.1; Met1-Arg370, Gly 75 Ala) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.1% sodium azide |
| 研究背景 | Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Protein: Human SIRPA / CD172A protein (TMPY-01573) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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