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Anti-SIGIRR Antibody (6K128)
还可以产品编号 TMAY-02261
Anti-SIGIRR Antibody (6K128) 是一种 Rabbit 抗体，靶向 SIGIRR。Anti-SIGIRR Antibody (6K128) 可用于 FCM。
Anti-SIGIRR Antibody (6K128)
Anti-SIGIRR Antibody (6K128)
还可以产品编号 TMAY-02261
Anti-SIGIRR Antibody (6K128) 是一种 Rabbit 抗体，靶向 SIGIRR。Anti-SIGIRR Antibody (6K128) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SIGIRR Antibody (6K128) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (6K128) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6K128 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human SIGIRR expression on SW480 cells. Cells were stained with purified anti-Human SIGIRR, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | PE |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human SIGIRR/TIR8 Protein (TMPY-01894) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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