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顶部生物活性储存和溶解信息计算器

Anti-SIGIRR Antibody (6K128)

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Anti-SIGIRR Antibody (6K128)
产品编号 TMAY-02261
别名 TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Anti-SIGIRR Antibody (6K128) 是一种 Rabbit 抗体，靶向 SIGIRR。Anti-SIGIRR Antibody (6K128) 可用于 FCM。

Anti-SIGIRR Antibody (6K128)
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Anti-SIGIRR Antibody (6K128)

Rating icon 还可以
Anti-SIGIRR Antibody (6K128)
产品编号 TMAY-02261 别名 TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Anti-SIGIRR Antibody (6K128) 是一种 Rabbit 抗体，靶向 SIGIRR。Anti-SIGIRR Antibody (6K128) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-SIGIRR Antibody (6K128) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (6K128) can be used in FCM.
别名TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Ig Type
Rabbit IgG
克隆号
6K128
交叉反应
Human
验证活性
Flow cytometric analysis of Human SIGIRR expression on SW480 cells. Cells were stained with purified anti-Human SIGIRR, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
PE
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human SIGIRR/TIR8 Protein (TMPY-01894)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

TIR-8TIR 8

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