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Anti-Securin Antibody (7P480)
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产品编号 TMAC-03701
别名 TUTR1, TUTR 1, Tumor-transforming protein 1, Tumor transforming protein 1, Tumor transforming 1, Securin, Pttg3, PTTG1_HUMAN, PTTG1 protein, PTTG1, PTTG 1, PTTG, Pituitary tumor-transforming gene 1 protein, Pituitary tumor-transforming gene 1, Pituitary tumor-transforming 1, isoform CRA_b, Pituitary tumor-transforming 1, isoform CRA_a, Pituitary tumor transforming protein 1, Pituitary tumor transforming 1, Pds1, MGC138276, MGC126883, hPTTG, Esp1-associated protein, ESP1 associated protein 1, EAP1, EAP 1, Cut2, C87862, AW555095
Anti-Securin Antibody (7P480) 是一种 Rabbit 抗体，靶向 Securin。Anti-Securin Antibody (7P480) 可用于 WB,ICC,IF,IHC,FCM,IP。
Anti-Securin Antibody (7P480)
Anti-Securin Antibody (7P480)
还可以产品编号 TMAC-03701 别名 TUTR1, TUTR 1, Tumor-transforming protein 1, Tumor transforming protein 1, Tumor transforming 1, Securin, Pttg3, PTTG1_HUMAN, PTTG1 protein, PTTG1, PTTG 1, PTTG, Pituitary tumor-transforming gene 1 protein, Pituitary tumor-transforming gene 1, Pituitary tumor-transforming 1, isoform CRA_b, Pituitary tumor-transforming 1, isoform CRA_a, Pituitary tumor transforming protein 1, Pituitary tumor transforming 1, Pds1, MGC138276, MGC126883, hPTTG, Esp1-associated protein, ESP1 associated protein 1, EAP1, EAP 1, Cut2, C87862, AW555095
Anti-Securin Antibody (7P480) 是一种 Rabbit 抗体，靶向 Securin。Anti-Securin Antibody (7P480) 可用于 WB,ICC,IF,IHC,FCM,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
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抗原信息
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| 产品描述 | Anti-Securin Antibody (7P480) is a Rabbit antibody targeting Securin. Anti-Securin Antibody (7P480) can be used in WB,ICC,IF,IHC,FCM,IP. |
| 别名 | TUTR1, TUTR 1, Tumor-transforming protein 1, Tumor transforming protein 1, Tumor transforming 1, Securin, Pttg3, PTTG1_HUMAN, PTTG1 protein, PTTG1, PTTG 1, PTTG, Pituitary tumor-transforming gene 1 protein, Pituitary tumor-transforming gene 1, Pituitary tumor-transforming 1, isoform CRA_b, Pituitary tumor-transforming 1, isoform CRA_a, Pituitary tumor transforming protein 1, Pituitary tumor transforming 1, Pds1, MGC138276, MGC126883, hPTTG, Esp1-associated protein, ESP1 associated protein 1, EAP1, EAP 1, Cut2, C87862, AW555095 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Securin on SiHa cell lysate using anti-Securin antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Securin antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Securin antibody. Counter stained with hematoxylin. 4. ICC staining Securin in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Securin in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Securin in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of A431 cells with Securin antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 22 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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