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Anti-RhoA Antibody (4W246)
还可以产品编号 TMAY-02350
Anti-RhoA Antibody (4W246) 是一种 Rabbit 抗体，靶向 RhoA。Anti-RhoA Antibody (4W246) 可用于 FCM。
Anti-RhoA Antibody (4W246)
Anti-RhoA Antibody (4W246)
还可以产品编号 TMAY-02350
Anti-RhoA Antibody (4W246) 是一种 Rabbit 抗体，靶向 RhoA。Anti-RhoA Antibody (4W246) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-RhoA Antibody (4W246) is a Rabbit antibody targeting RhoA. Anti-RhoA Antibody (4W246) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4W246 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human RHOA expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human RHOA, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human RhoA (rh RhoA; TMPY-01958; P61586-1; Met1-Leu193). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamily; proteins involved in the regulation and timing of cell division. RHOA / ARH12 is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. It acts upon two known effector proteins: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 ( diaphanous homolog 1 (Drosophila) ). RHOA / ARH12 regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA / ARH12 serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RHOA / ARH12 may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human RhoA Protein (TMPY-01958) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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