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Anti-RAP1GAP Antibody (4C780)
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产品编号 TMAC-03533
别名 RPGP1_HUMAN, RAPGAP, RAP1GAPII, Rap1GAP1, Rap1GAP, Rap1ga1 protein, RAP1GA1, Rap1 GTPase-activating protein 1, Rap1 GTPase activating protein 1, RAP1 GTPase activating protein, KIAA0474
Anti-RAP1GAP Antibody (4C780) 是一种 Mouse 抗体，靶向 RAP1GAP。Anti-RAP1GAP Antibody (4C780) 可用于 WB,FCM。
Anti-RAP1GAP Antibody (4C780)
Anti-RAP1GAP Antibody (4C780)
还可以产品编号 TMAC-03533 别名 RPGP1_HUMAN, RAPGAP, RAP1GAPII, Rap1GAP1, Rap1GAP, Rap1ga1 protein, RAP1GA1, Rap1 GTPase-activating protein 1, Rap1 GTPase activating protein 1, RAP1 GTPase activating protein, KIAA0474
Anti-RAP1GAP Antibody (4C780) 是一种 Mouse 抗体，靶向 RAP1GAP。Anti-RAP1GAP Antibody (4C780) 可用于 WB,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,985 | 5日内发货 | |
| 100 μL | ¥ 2,995 | 5日内发货 |
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| 产品描述 | Anti-RAP1GAP Antibody (4C780) is a Mouse antibody targeting RAP1GAP. Anti-RAP1GAP Antibody (4C780) can be used in WB,FCM. |
| 别名 | RPGP1_HUMAN, RAPGAP, RAP1GAPII, Rap1GAP1, Rap1GAP, Rap1ga1 protein, RAP1GA1, Rap1 GTPase-activating protein 1, Rap1 GTPase activating protein 1, RAP1 GTPase activating protein, KIAA0474 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of RAP1GAP on human RAP1GAP recombinant protein using anti-RAP1GAP antibody at 1/1,000 dilution. 2. Western blot analysis of RAP1GAP on HEK293 (1) and RAP1GAP-hIgGFc transfected HEK293 (2) cell lysate using anti-RAP1GAP antibody at 1/1,000 dilution. 3. Flow cytometric analysis of A431 cells with RAP1GAP antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red). |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Rap1 GTPase activating protein (Rap1GAP) specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between Gα z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the α subunit, and also attenuates the ability of activated Gα z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to Gα z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 73 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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