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Anti-Prolactin Receptor Antibody-APC (8B416)
还可以产品编号 TMAY-00549A
Anti-Prolactin Receptor Antibody-APC (8B416) 是一种 APC-conjugated Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody-APC (8B416) 可用于 FCM。
Anti-Prolactin Receptor Antibody-APC (8B416)
Anti-Prolactin Receptor Antibody-APC (8B416)
还可以产品编号 TMAY-00549A
Anti-Prolactin Receptor Antibody-APC (8B416) 是一种 APC-conjugated Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody-APC (8B416) 可用于 FCM。
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| 产品描述 | Anti-Prolactin Receptor Antibody-APC (8B416) is a APC-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-APC (8B416) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8B416 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human PRLR expression on MCF-7 cells. MCF-7 cells were stained with APC-conjugated anti-Human PRLR. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Prolactin Receptor / PRLR (rh Prolactin Receptor / PRLR; TMPY-01053; NP_000940.1; Met1-Asp234) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/HRP/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human Prolactin Receptor / PRLR protein (TMPY-01053) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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