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Anti-Prolactin Receptor Antibody-APC (8B416)

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Anti-Prolactin Receptor Antibody-APC (8B416)
产品编号 TMAY-00549A
别名 prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712

Anti-Prolactin Receptor Antibody-APC (8B416) 是一种 APC-conjugated Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody-APC (8B416) 可用于 FCM。

Anti-Prolactin Receptor Antibody-APC (8B416)
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Anti-Prolactin Receptor Antibody-APC (8B416)

Rating icon 还可以
Anti-Prolactin Receptor Antibody-APC (8B416)
产品编号 TMAY-00549A 别名 prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712

Anti-Prolactin Receptor Antibody-APC (8B416) 是一种 APC-conjugated Rabbit 抗体，靶向 Prolactin Receptor。Anti-Prolactin Receptor Antibody-APC (8B416) 可用于 FCM。

规格价格库存数量
25 T
¥ 1,095
5日内发货
100 T
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-Prolactin Receptor Antibody-APC (8B416) is a APC-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-APC (8B416) can be used in FCM.
别名prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Ig Type
Rabbit IgG
克隆号
8B416
交叉反应
Human
验证活性
Flow cytometric analysis of human PRLR expression on MCF-7 cells. MCF-7 cells were stained with APC-conjugated anti-Human PRLR. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
10 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human Prolactin Receptor / PRLR (rh Prolactin Receptor / PRLR; TMPY-01053; NP_000940.1; Met1-Asp234) and conjugated with APC under optimum conditions, the unreacted APC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.03%ProClin300
研究背景Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.
偶联与修饰
偶联
APC
其他可选修饰符
Unconjugated/HRP/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human Prolactin Receptor / PRLR protein (TMPY-01053)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
运输方式Shipping with blue ice.

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关键词

AI-987712AI 987712

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