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Anti-PIN1 Antibody (3P694)

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货号 TMAB-11459

Anti-PIN1 Antibody (3P694) 是一种 Mouse 抗体，靶向 PIN1。Anti-PIN1 Antibody (3P694) 可用于 WB,ELISA,IHC-P,IHC-Fr,IF。

Anti-PIN1 Antibody (3P694)

Anti-PIN1 Antibody (3P694)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11459

Anti-PIN1 Antibody (3P694) 是一种 Mouse 抗体，靶向 PIN1。Anti-PIN1 Antibody (3P694) 可用于 WB,ELISA,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
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产品介绍

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产品描述
Anti-PIN1 Antibody (3P694) is a Mouse antibody targeting PIN1. Anti-PIN1 Antibody (3P694) can be used in WB,ELISA,IHC-P,IHC-Fr,IF.
Ig Type
IgG1
克隆号
3P694
反应种属
Human,Mouse,Rat (predicted:Monkey)
应用WBELISAIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; ELISA: 1:5000-10000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. Nucleus speckle. Cytoplasm.
组织特异性The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液PBS with 0.02% Proclin300.
浓度1mg/ml
研究背景Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PIN1
抗原种属
Human
基因名称
PIN1
基因ID
5300
蛋白名称
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Uniprot ID
Q13526
功能
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
化学信息
分子量Theoretical: 18 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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