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Anti-Phospho-IRF3 (Ser386) Antibody (7A218)

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Anti-Phospho-IRF3 (Ser386) Antibody (7A218)
产品编号 TMAH-00912
别名 p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7

Anti-Phospho-IRF3 (Ser386) Antibody (7A218) 是一种抗体，靶向 Phospho-IRF3 (Ser386)。Anti-Phospho-IRF3 (Ser386) Antibody (7A218) 可用于 ELISA, WB。

Anti-Phospho-IRF3 (Ser386) Antibody (7A218)

Anti-Phospho-IRF3 (Ser386) Antibody (7A218)

Rating icon 还可以
Anti-Phospho-IRF3 (Ser386) Antibody (7A218)
产品编号 TMAH-00912 别名 p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7

Anti-Phospho-IRF3 (Ser386) Antibody (7A218) 是一种抗体，靶向 Phospho-IRF3 (Ser386)。Anti-Phospho-IRF3 (Ser386) Antibody (7A218) 可用于 ELISA, WB。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-IRF3 (Ser386) Antibody (7A218) is an antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Antibody (7A218) can be used in ELISA, WB.
别名p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7
Ig Type
Rabbit IgG
克隆号
7A218
交叉反应
Human
验证活性
Western Blot
-Positive WB detected in Hela whole cell lysate(treated with Calyculin A or not)
-All lanes Phospho-IRF3 antibody at 1.03μg/ml
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 47 KDa
-Observed band size: 47 KDa
应用
ELISA
WB
推荐剂量
WB:1:500-1:5000.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Nucleus. Mitochondrion.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Phospho-IRF3 (S386)
抗原种属
Human
基因ID
3661
Uniprot ID
Q14653
研究领域
Immunology
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pIRF3 (Ser386)pIRF3 (S386)IRF3 (pSer386)IRF3 (pS386)IRF3 (phospho-Ser386)IRF3 (phospho-S386)

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