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顶部生物活性储存和溶解信息计算器

Anti-Phospho-EGFR (Tyr1068) Antibody (4G610)

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Anti-Phospho-EGFR (Tyr1068) Antibody (4G610)
产品编号 TMAC-03208
别名 p-EGFR (Y1068), p-EGFR (Tyr1068), EGFR (p-Y1068), EGFR (p-Tyr1068)

Anti-Phospho-EGFR (Y1068) Antibody (4G610) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (Y1068)。Anti-Phospho-EGFR (Y1068) Antibody (4G610) 可用于 WB,ICC/IF,IP,FCM。

Anti-Phospho-EGFR (Tyr1068) Antibody (4G610)

Anti-Phospho-EGFR (Tyr1068) Antibody (4G610)

Rating icon 还可以
Anti-Phospho-EGFR (Tyr1068) Antibody (4G610)
产品编号 TMAC-03208 别名 p-EGFR (Y1068), p-EGFR (Tyr1068), EGFR (p-Y1068), EGFR (p-Tyr1068)

Anti-Phospho-EGFR (Y1068) Antibody (4G610) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (Y1068)。Anti-Phospho-EGFR (Y1068) Antibody (4G610) 可用于 WB,ICC/IF,IP,FCM。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-EGFR (Tyr1068) Antibody (4G610) 是一种 Rabbit 抗体，靶向 Phospho-EGFR (Tyr1068)。Anti-Phospho-EGFR (Tyr1068) Antibody (4G610) 可用于 WB,ICC/IF,IP,FCM。
别名p-EGFR (Y1068), p-EGFR (Tyr1068), EGFR (p-Y1068), EGFR (p-Tyr1068)
Ig Type
IgG
交叉反应
Human
验证活性
1. ICC staining Phospho-EGFR (Y1068) in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
2. ICC staining Phospho-EGFR (Y1068) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining Phospho-EGFR (Y1068) in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of Hela cells with Phospho-EGFR (Y1068) antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IP
FCM
推荐剂量
WB: 1:1000; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Epidermal growth factor mediates its effects on cell growth through its inter-action with a cell surface glycoprotein designated the EGF receptor. Binding of EGF or TGF alpha to the EGF receptor activates tyrosine-specific protein kinase activity intrinsic to the EGF receptor. The carboxy terminal tyrosine residues on EGFR, Tyr 1068 and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding. Once activated, EGFR mediates the binding of the phosphotyrosine binding (PTB) domain of GRB2 through direct interactions with Tyr 1068 and Tyr 1086 and through indirect interactions with Tyr 1173 in the Ras signaling pathway. Tyr 1173 of EGFR also functions as a kinase substrate. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal tail of the EGF receptor.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human EGFR around the phosphorylation site of Tyr1068
抗原种属
human
Uniprot ID
P00533
化学信息
分子量Theoretical: 175 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pEGFR (Y1068)pEGFR (Tyr1068)EGFR (pY1068)EGFR (pTyr1068)EGFR (phospho-Y1068)EGFR (phospho-Tyr1068)

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4个月前
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