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Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-CREB1 (Ser133)。Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Phospho-CREB1 (Ser133)。Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody 可用于 WB,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,495 | 5日内发货 | |
100 μL | ¥ 2,235 | 5日内发货 |
产品描述 | Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CREB1 (Ser133). Anti-Phospho-CREB1 (Ser133) Polyclonal Antibody can be used in WB,IHC. |
别名 | p-CREB1 (Ser133), p-CREB1 (S133), CREB1 (p-Ser133), CREB1 (p-S133) |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of extracts from Hela cells untreated or treated with UV using CREB (Phospho-Ser133) Antibody TMAC-00966. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Phospho-Ser133) Antibody TMAC-00966 (left) or the same antibody preincubated with blocking peptide (right). |
应用 | |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
性状 | Liquid |
缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
研究背景 | CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories . |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R) derived from Human CREB |
抗原种属 | human |
Uniprot ID |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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