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Anti-Phospho-CREB (Ser133) Antibody (1Q730)
还可以产品编号 TMAY-01558
Anti-Phospho-CREB (Ser133) Antibody (1Q730) 是一种 Rabbit 抗体，靶向 Phospho-CREB (Ser133)。Anti-Phospho-CREB (Ser133) Antibody (1Q730) 可用于 WB,IHC-P。
Anti-Phospho-CREB (Ser133) Antibody (1Q730)
Anti-Phospho-CREB (Ser133) Antibody (1Q730)
还可以产品编号 TMAY-01558
Anti-Phospho-CREB (Ser133) Antibody (1Q730) 是一种 Rabbit 抗体，靶向 Phospho-CREB (Ser133)。Anti-Phospho-CREB (Ser133) Antibody (1Q730) 可用于 WB,IHC-P。
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| 产品描述 | Anti-Phospho-CREB (Ser133) Antibody (1Q730) is a Rabbit antibody targeting Phospho-CREB (Ser133). Anti-Phospho-CREB (Ser133) Antibody (1Q730) can be used in WB,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1Q730 |
| 交叉反应 | Human; Predicted to React with:Phospho-CREB (Ser133), may cross with Phospho-ATF-1 (Ser63) by sequence similarity. Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Bovine, Pig, Goat |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with TPA (200 nM, 15 min; +), using Phospho-CREB (Ser133) rabbit monoclonal Antibody at 1:200000 dilution (upper) or Anti-CREB Antibody, Rabbit Polyclonal at 1:500 dilution (middle) or Beta-Tubulin Loading Control Antibody, Rabbit MAb (Chimeric) at 1:40000 dilution (lower). Phospho-CREB (Ser133) rabbit monoclonal Antibody may cross with Phospho-ATF-1 (Ser63) by sequence similarity. 2. Immunohistochemical analysis of paraffin-embedded human breast cancer, untreated (left) or lambda phosphatase-treated (right), using Phospho-CREB (Ser133) Antibody, Rabbit Monoclonal at 1:200 dilution. 3. Immunohistochemical analysis of paraffin-embedded human lung cancer, untreated (left) or lambda phosphatase-treated (right), using Phospho-CREB (Ser133) Antibody, Rabbit Monoclonal at 1:200 dilution. 4. Immunohistochemical analysis of paraffin-embedded human renal carcinoma, untreated (left) or lambda phosphatase-treated (right), using Phospho-CREB (Ser133) Antibody, Rabbit Monoclonal at 1:200 dilution. 5. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with TPA (100 nM, 15 min) (line B); treated with TPA and λ-phosphatase (line C) using Phospho-CREB (Ser133) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment) 6. Western blot analysis of extracts from serum-starved Hela, untreated (line A); treated with TPA (100 nM, 15 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-CREB (Ser133) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment) 7. Western blot analysis of extracts from serum-starved Hela treated with TPA (100 nM, 15 min), using Phospho-CREB (Ser133) rabbit monoclonal Antibody at 1:10000, 1:100000, 1:500000 dilution. (Validation Experiment) |
| 应用 | WB,IHC-P |
| 推荐剂量 | WB: 1:10000-1:200000; IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Ser133 of human CREB. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | CAMP responsive element binding protein 1, also known as CREB-1, plays multiple functions as a transcription factor in gene regulation. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators.The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB-1 has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. CREB-1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around Ser133 of human CREB. |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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