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顶部生物活性储存和溶解信息计算器

Anti-Phospho-C-Myc (Thr58/Ser62) Polyclonal Antibody

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产品编号 TMAB-10273

种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit)

Anti-Phospho-C-Myc (Thr58/Ser62) Polyclonal Antibody

Anti-Phospho-C-Myc (Thr58/Ser62) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAB-10273

种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit)

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产品介绍

生物活性
产品描述
Anti-Phospho-C-Myc (Thr58/Ser62) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-Myc (Thr58/Ser62). Anti-Phospho-C-Myc (Thr58/Ser62) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus, nucleoplasm.
组织特异性Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human c-Myc around the phosphorylation site of Thr58 and Ser62
抗原种属
Human
基因名称
MYC
基因ID
4609
蛋白名称
Myc proto-oncogene protein
Uniprot ID
P01106
功能
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
化学信息
分子量Theoretical: 49 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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