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Anti-Phospho-C-Myc (Thr58) Polyclonal Antibody
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还可以产品编号 TMAB-10527
种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit)
Anti-Phospho-C-Myc (Thr58) Polyclonal Antibody
Anti-Phospho-C-Myc (Thr58) Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-10527
种类：Rabbit Polyclonal
应用：IHC-P,IHC-Fr,IF
交叉反应：Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit)
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| 产品描述 | Anti-Phospho-C-Myc (Thr58) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-Myc (Thr58). Anti-Phospho-C-Myc (Thr58) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit) |
| 应用 | IHC-PIHC-FrIF |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nucleus, nucleoplasm. |
| 组织特异性 | Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]. |
| 免疫原 | KLH conjugated Synthesised phosphopeptide: human C-Myc around the phosphorylation site of Thr58 |
| 抗原种属 | Human |
| 基因名称 | MYC |
| 基因ID | |
| 蛋白名称 | Myc proto-oncogene protein |
| Uniprot ID | |
| 功能 | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. |
| 分子量 | Theoretical: 49 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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