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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PCGF4/BMI1 Polyclonal Antibody

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货号 TMAB-10065

Anti-PCGF4/BMI1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PCGF4/BMI1。Anti-PCGF4/BMI1 Polyclonal Antibody 可用于 WB,FCM。

Anti-PCGF4/BMI1 Polyclonal Antibody

Anti-PCGF4/BMI1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10065

Anti-PCGF4/BMI1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PCGF4/BMI1。Anti-PCGF4/BMI1 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-PCGF4/BMI1 Polyclonal Antibody is a Rabbit antibody targeting PCGF4/BMI1. Anti-PCGF4/BMI1 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Cow,Rabbit)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Bmi1/PCGF4
抗原种属
Human
基因名称
BMI1
基因ID
100532731
蛋白名称
Polycomb complex protein BMI-1
Uniprot ID
P35226
功能
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
化学信息
分子量Theoretical: 37 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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