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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NrCAM Polyclonal Antibody

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货号 TMAB-09633

Anti-NrCAM Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NrCAM。Anti-NrCAM Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-NrCAM Polyclonal Antibody

Anti-NrCAM Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-09633

Anti-NrCAM Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NrCAM。Anti-NrCAM Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍

生物活性
产品描述
Anti-NrCAM Polyclonal Antibody is a Rabbit antibody targeting NrCAM. Anti-NrCAM Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Mouse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
组织特异性Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31.1-q31.2.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse NrCAM
抗原种属
Mouse
基因名称
NRCAM
基因ID
319504
蛋白名称
Neuronal cell adhesion molecule
Uniprot ID
Q810U4
功能
Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier.
化学信息
分子量Theoretical: 141 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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