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Anti-NDRG1 Antibody (4F195)

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货号 TMAB-09300

Anti-NDRG1 Antibody (4F195) 是一种 Rabbit 抗体，靶向 NDRG1。Anti-NDRG1 Antibody (4F195) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,IP。

Anti-NDRG1 Antibody (4F195)

Anti-NDRG1 Antibody (4F195)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09300

Anti-NDRG1 Antibody (4F195) 是一种 Rabbit 抗体，靶向 NDRG1。Anti-NDRG1 Antibody (4F195) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,IP。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-NDRG1 Antibody (4F195) is a Rabbit antibody targeting NDRG1. Anti-NDRG1 Antibody (4F195) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP.
Ig Type
IgG
克隆号
4F195
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIFIP
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytosol. Cytoplasm, cytoskeleton, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
组织特异性Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking.
抗原信息
免疫原
A synthesized peptide: human NDRG1
抗原种属
Human
基因名称
NDRG1
基因ID
10397
蛋白名称
Protein NDRG1
Uniprot ID
Q92597
功能
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
化学信息
分子量Theoretical: 43 kDa. Actual: 43 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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