Anti-MRPL49 Polyclonal Antibody is a Rabbit antibody targeting MRPL49. Anti-MRPL49 Polyclonal Antibody can be used in WB.

IgG

Human (predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep)

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human MRPL49

Human

MRPL49

39S ribosomal protein L49, mitochondrial

Mitochondria have their own translation system for production of 13 inner membrane proteins essential for oxidative phosphorylation. MRPL49 is a component of the large subunit of the mitochondrial ribosome that is encoded by the nuclear genome. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for the HRD1 protein use in their respective 3' UTRs some of the same genomic sequence. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p.