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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-mouse CD19 Antibody (5M385)

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货号 TMAB-08951

Anti-mouse CD19 Antibody (5M385) 是一种 Rat 抗体，靶向 mouse CD19。Anti-mouse CD19 Antibody (5M385) 可用于 FCM。

Anti-mouse CD19 Antibody (5M385)

Anti-mouse CD19 Antibody (5M385)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08951

Anti-mouse CD19 Antibody (5M385) 是一种 Rat 抗体，靶向 mouse CD19。Anti-mouse CD19 Antibody (5M385) 可用于 FCM。

规格价格库存数量
100 μg
¥ 1,870
5日内发货
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产品介绍

生物活性
产品描述
Anti-mouse CD19 Antibody (5M385) is a Rat antibody targeting mouse CD19. Anti-mouse CD19 Antibody (5M385) can be used in FCM.
Ig Type
Rat IgG2a,k
克隆号
5M385
反应种属
Mouse
应用FCM
推荐剂量
FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rat
亚细胞定位Membrane; Single-pass type I membrane protein.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4).
研究背景This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]
抗原信息
基因名称
CD19
基因ID
930
蛋白名称
B-lymphocyte antigen CD19
功能
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
化学信息
分子量Theoretical: 59 kDa. Actual: 90 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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