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Anti-MAP3K3 Antibody (2Q519)
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产品编号 TMAC-02557
别名 Mitogen activated protein kinase kinase kinase 3, MEKK3, MEKK 3, MEK kinase 3, MAPKKK3, MAPK/ERK kinase kinase 3, MAP/ERK kinase kinase 3, M3K3_HUMAN
Anti-MAP3K3 Antibody (2Q519) 是一种 Rabbit 抗体，靶向 MAP3K3。Anti-MAP3K3 Antibody (2Q519) 可用于 WB,ICC/IF,IHC,IP,FCM。
Anti-MAP3K3 Antibody (2Q519)
Anti-MAP3K3 Antibody (2Q519)
还可以产品编号 TMAC-02557 别名 Mitogen activated protein kinase kinase kinase 3, MEKK3, MEKK 3, MEK kinase 3, MAPKKK3, MAPK/ERK kinase kinase 3, MAP/ERK kinase kinase 3, M3K3_HUMAN
Anti-MAP3K3 Antibody (2Q519) 是一种 Rabbit 抗体，靶向 MAP3K3。Anti-MAP3K3 Antibody (2Q519) 可用于 WB,ICC/IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-MAP3K3 Antibody (2Q519) is a Rabbit antibody targeting MAP3K3. Anti-MAP3K3 Antibody (2Q519) can be used in WB,ICC/IF,IHC,IP,FCM. |
| 别名 | Mitogen activated protein kinase kinase kinase 3, MEKK3, MEKK 3, MEK kinase 3, MAPKKK3, MAPK/ERK kinase kinase 3, MAP/ERK kinase kinase 3, M3K3_HUMAN |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of MEKK3 on different lysates using anti-MEKK3 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: 293T, Lane 3: A431. 2. Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-MEKK3 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat uterus tissue using anti-MEKK3 antibody. Counter stained with hematoxylin. 4. ICC staining MEKK3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining MEKK3 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining MEKK3 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Hela cells with MEKK3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2. MEKK3 also stimulates MEK5 via activation of ERK5/BMK1, which is at least partly regulated by a direct interaction between MEK5 and MEKK3 via p67phox-Bem1p (PB1) protein-protein interaction domains found in both proteins. MEKK3 modulates NF-κB activation in response to a variety of agonists including TNFα, LPS, IL-1 and LPA. Despite reports showing that phosphorylation of MEKK3 at Ser526 within the activation loop is necessary for kinase activation, at least one study suggests that dual phosphorylation at Thr516 and Ser520 is required for LPA-stimulated IKKβ/NF-κB activation. Phosphorylation at Thr294 appears to negatively regulate MEKK3 by promoting 14-3-3β binding and inhibition of the kinase activity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 71 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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