购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MAML1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-08538

Anti-MAML1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAML1。Anti-MAML1 Polyclonal Antibody 可用于 WB。

Anti-MAML1 Polyclonal Antibody

Anti-MAML1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-08538

Anti-MAML1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAML1。Anti-MAML1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-MAML1 Polyclonal Antibody is a Rabbit antibody targeting MAML1. Anti-MAML1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus speckle. Nuclear, in a punctate manner.
组织特异性Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).
抗原信息
免疫原
KLH conjugated synthetic peptide: human MAML1
抗原种属
Human
基因名称
MAML1
基因ID
9794
蛋白名称
Mastermind-like protein 1
Uniprot ID
Q92585
功能
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
化学信息
分子量Theoretical: 108 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-MAML1 Polyclonal Antibody | purchase Anti-MAML1 Polyclonal Antibody | Anti-MAML1 Polyclonal Antibody cost | order Anti-MAML1 Polyclonal Antibody | Anti-MAML1 Polyclonal Antibody molecular weight