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Anti-L-selectin Antibody (4Y137)
还可以产品编号 TMAY-02084
Anti-L-selectin Antibody (4Y137) 是一种 Mouse 抗体，靶向 L-selectin。Anti-L-selectin Antibody (4Y137) 可用于 ELISA,FCM。
Anti-L-selectin Antibody (4Y137)
Anti-L-selectin Antibody (4Y137)
还可以产品编号 TMAY-02084
Anti-L-selectin Antibody (4Y137) 是一种 Mouse 抗体，靶向 L-selectin。Anti-L-selectin Antibody (4Y137) 可用于 ELISA,FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-L-selectin Antibody (4Y137) is a Mouse antibody targeting L-selectin. Anti-L-selectin Antibody (4Y137) can be used in ELISA,FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4Y137 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human SELL(CD62L) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human SELL(CD62L), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | ELISA,FCM |
| 推荐剂量 | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD62L / L-Selectin / SELL (rh CD62L / L-Selectin / SELL; TMPY-02024; P14151-1; Met1-Asn332). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD62L / L-Selectin / SELL Protein (TMPY-02024) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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