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顶部生物活性储存和溶解信息计算器

Anti-IQGAP1 Antibody (5T212)

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产品编号 TMAC-02204

别名 SAR1, RasGAP-like with IQ motifs, Ras GTPase-activating-like protein IQGAP1, Ras GTPase activating like protein 1, p195, KIAA0051, Iqgap 1, IQGA1_HUMAN, IQ motif containing GTPase activating protein 1, HUMORFA01

Anti-IQGAP1 Antibody (5T212) 是一种 Rabbit 抗体，靶向 IQGAP1。Anti-IQGAP1 Antibody (5T212) 可用于 FCM,ICC,IF,IHC,WB。

Anti-IQGAP1 Antibody (5T212)

Anti-IQGAP1 Antibody (5T212)

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产品编号 TMAC-02204 别名 SAR1, RasGAP-like with IQ motifs, Ras GTPase-activating-like protein IQGAP1, Ras GTPase activating like protein 1, p195, KIAA0051, Iqgap 1, IQGA1_HUMAN, IQ motif containing GTPase activating protein 1, HUMORFA01

Anti-IQGAP1 Antibody (5T212) 是一种 Rabbit 抗体，靶向 IQGAP1。Anti-IQGAP1 Antibody (5T212) 可用于 FCM,ICC,IF,IHC,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-IQGAP1 Antibody (5T212) is a Rabbit antibody targeting IQGAP1. Anti-IQGAP1 Antibody (5T212) can be used in FCM,ICC,IF,IHC,WB.
别名SAR1, RasGAP-like with IQ motifs, Ras GTPase-activating-like protein IQGAP1, Ras GTPase activating like protein 1, p195, KIAA0051, Iqgap 1, IQGA1_HUMAN, IQ motif containing GTPase activating protein 1, HUMORFA01
Ig Type
IgG
克隆号
5T212
交叉反应
Human,Mouse
验证活性
1. Western blot analysis of IQGAP1 on different lysates using anti-IQGAP1 antibody at 1/1,000 dilution. Positive control: Lane 1: HUVEC, Lane 2: A431, Lane 3: Mouse placenta.
2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-IQGAP1 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-IQGAP1 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-IQGAP1 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-IQGAP1 antibody. Counter stained with hematoxylin.
6. ICC staining IQGAP1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining IQGAP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining IQGAP1 in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. Flow cytometric analysis of SiHa cells with IQGAP1 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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应用FCMICCIFIHCWB
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; ICC:IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景IQGAP1, for IQ motif containing GTPase activating protein, is a Ras GAP-related, Actin-binding protein that interacts with the small GTPases Cdc42 and Rac1. The C-terminus of IQGAP1 is essential for interacting with Cdc42 and, in addition, IQGAP1 contains a WW domain and a predicted N-terminal coiled-coil region, which may be involved in IQGAP dimerization. Expression of IQGAP1 is highest in placenta, lung and kidney, where it co-localizes with Cdc42 to the cytoskeleton and assists with Cdc42 in mediating the regulation of cell proliferation, polarity and cell morphology. IQGAP1 regulates cadherin-mediated cell adhesion via binding to E-cadherin, b-catenin and a-catenin. This association induces the accumulation of these proteins at the site of cell-cell contact. IQGAP1 is negatively regulated by calmodulin, which binds to IQGAP1 in a calcium-dependent manner and disrupts IQGAP1 from associating with Cdc42.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: N-terminal human IQGAP1
抗原种属
human
Uniprot ID
P46940
化学信息
分子量Theoretical: 189 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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