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Anti-Insulin Receptor Antibody-PE (6Y412)
还可以产品编号 TMAY-01626P
Anti-Insulin Receptor Antibody-PE (6Y412) 是一种 PE-conjugated Mouse 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody-PE (6Y412) 可用于 FCM。
Anti-Insulin Receptor Antibody-PE (6Y412)
Anti-Insulin Receptor Antibody-PE (6Y412)
还可以产品编号 TMAY-01626P
Anti-Insulin Receptor Antibody-PE (6Y412) 是一种 PE-conjugated Mouse 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody-PE (6Y412) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-Insulin Receptor Antibody-PE (6Y412) is a PE-conjugated Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody-PE (6Y412) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6Y412 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human INSR(CD220) expression on human whole blood monocytes. Cells were stained with PE-conjugated anti-Human INSR(CD220). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin Receptor/INSR/CD220 (rh Insulin Receptor/INSR/CD220; TMPY-01149; NP_001073285.1; Met1-Lys944) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM). |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human Insulin Receptor/INSR/CD220 Protein (TMPY-01149) |
| 抗原种属 | Human |
| 研究领域 | Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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