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Anti-IL-6R Antibody-PE (5X839)
还可以产品编号 TMAY-03209P
Anti-IL-6R Antibody-PE (5X839) 是一种 PE-conjugated Rabbit 抗体，靶向 IL-6R。Anti-IL-6R Antibody-PE (5X839) 可用于 FCM。
Anti-IL-6R Antibody-PE (5X839)
Anti-IL-6R Antibody-PE (5X839)
还可以产品编号 TMAY-03209P
Anti-IL-6R Antibody-PE (5X839) 是一种 PE-conjugated Rabbit 抗体，靶向 IL-6R。Anti-IL-6R Antibody-PE (5X839) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-6R Antibody-PE (5X839) is a PE-conjugated Rabbit antibody targeting IL-6R. Anti-IL-6R Antibody-PE (5X839) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5X839 |
| 交叉反应 | Mouse |
| 验证活性 | Flow cytometric analysis of Mouse IL-6R expression on BABL/c splenocytes. Cells were stained with PE-conjugated anti-Human Mouse IL-6R. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-6R / CD126 (rM IL-6R / CD126; TMPY-01214; NP_034689.2; Ile44-Glu357) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse IL-6R / CD126 protein (TMPY-01214) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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