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Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
还可以产品编号 TMAY-00302F
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) 是一种 FITC-conjugated Mouse 抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) 可用于 FCM。
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
还可以产品编号 TMAY-00302F
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) 是一种 FITC-conjugated Mouse 抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) is a FITC-conjugated Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 2C850 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of anti-human IL1R3 on human whole blood monocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; TMPY-01251; NP_002173.1; Met 1-Glu 359) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.1% sodium azide |
| 研究背景 | Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/APC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human IL-1RAcP / IL-1R3 protein (TMPY-01251) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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