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Anti-IL-1R1 Antibody-FITC (5P116)
还可以产品编号 TMAY-03709F
Anti-IL-1R1 Antibody-FITC (5P116) 是一种 FITC-conjugated Rabbit 抗体，靶向 IL-1R1。Anti-IL-1R1 Antibody-FITC (5P116) 可用于 FCM。
Anti-IL-1R1 Antibody-FITC (5P116)
Anti-IL-1R1 Antibody-FITC (5P116)
还可以产品编号 TMAY-03709F
Anti-IL-1R1 Antibody-FITC (5P116) 是一种 FITC-conjugated Rabbit 抗体，靶向 IL-1R1。Anti-IL-1R1 Antibody-FITC (5P116) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-1R1 Antibody-FITC (5P116) is a FITC-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-FITC (5P116) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5P116 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of Rat IL1R1(CD121a) expression on rat splenocytes. SD splenocytes were stained with FITC-conjugated anti-Rat IL1R1(CD121a). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; TMPY-02059; NP_037255.3; Met1-Lys352) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Rat IL-1R1 / CD121a protein (TMPY-02059) |
| 抗原种属 | Rat |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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