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Anti-IL-1R1 Antibody (3F72)
还可以产品编号 TMAY-03470
Anti-IL-1R1 Antibody (3F72) 是一种 Rabbit 抗体，靶向 IL-1R1。Anti-IL-1R1 Antibody (3F72) 可用于 FCM。
Anti-IL-1R1 Antibody (3F72)
Anti-IL-1R1 Antibody (3F72)
还可以产品编号 TMAY-03470
Anti-IL-1R1 Antibody (3F72) 是一种 Rabbit 抗体，靶向 IL-1R1。Anti-IL-1R1 Antibody (3F72) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-1R1 Antibody (3F72) is a Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody (3F72) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3F72 |
| 交叉反应 | Mouse |
| 验证活性 | Flow cytometric analysis of IL1R1(CD121a) expression on NIH3T3 cells. Cells were stained with purified anti-Mouse IL1R1(CD121a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1R1 / CD121a (rM IL-1R1 / CD121a; TMPY-02341; P13504; Met1-Lys338). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse IL-1R1 / CD121a Protein (TMPY-02341) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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