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Anti-IL-17RD Antibody (8A53)
还可以产品编号 TMAY-00916
Anti-IL-17RD Antibody (8A53) 是一种 Rabbit 抗体，靶向 IL-17RD。Anti-IL-17RD Antibody (8A53) 可用于 ELISA(Cap)。
Anti-IL-17RD Antibody (8A53)
Anti-IL-17RD Antibody (8A53)
还可以产品编号 TMAY-00916
Anti-IL-17RD Antibody (8A53) 是一种 Rabbit 抗体，靶向 IL-17RD。Anti-IL-17RD Antibody (8A53) 可用于 ELISA(Cap)。
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偶联与修饰
抗原信息
| 产品描述 | Anti-IL-17RD Antibody (8A53) is a Rabbit antibody targeting IL-17RD. Anti-IL-17RD Antibody (8A53) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8A53 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-17RD (rh IL-17RD; TMPY-00844; NP_060033.3; Met1-Arg299). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Interleukin-17 receptor D (IL-17RD) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip, and dorsal regions of the myelencephalon and the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and the hippocampus, lens, and optic cup. In the oral region, IL-17RD is expressed in the tongue and the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD can affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. Also, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human IL-17RD Protein (TMPY-00844) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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