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Anti-IGFBP-3 Antibody-HRP (4I145)
还可以产品编号 TMAY-00820H
Anti-IGFBP-3 Antibody-HRP (4I145) 是一种 HRP-conjugated Rabbit 抗体，靶向 IGFBP-3。Anti-IGFBP-3 Antibody-HRP (4I145) 可用于 ELISA。
Anti-IGFBP-3 Antibody-HRP (4I145)
Anti-IGFBP-3 Antibody-HRP (4I145)
还可以产品编号 TMAY-00820H
Anti-IGFBP-3 Antibody-HRP (4I145) 是一种 HRP-conjugated Rabbit 抗体，靶向 IGFBP-3。Anti-IGFBP-3 Antibody-HRP (4I145) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-IGFBP-3 Antibody-HRP (4I145) is a HRP-conjugated Rabbit antibody targeting IGFBP-3. Anti-IGFBP-3 Antibody-HRP (4I145) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4I145 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human IGFBP3 (rh IGFBP3; TMPY-00835; Gly28-Lys 291; NP_000589.2), and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human IGFBP3 Protein (TMPY-00835) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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