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Anti-IGFBP-3 Antibody-HRP (4I145)

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Anti-IGFBP-3 Antibody-HRP (4I145)
产品编号 TMAY-00820H
别名 insulin-like growth factor binding protein 3

Anti-IGFBP-3 Antibody-HRP (4I145) 是一种 HRP-conjugated Rabbit 抗体，靶向 IGFBP-3。Anti-IGFBP-3 Antibody-HRP (4I145) 可用于 ELISA。

Anti-IGFBP-3 Antibody-HRP (4I145)
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Anti-IGFBP-3 Antibody-HRP (4I145)

Rating icon 还可以
Anti-IGFBP-3 Antibody-HRP (4I145)
产品编号 TMAY-00820H 别名 insulin-like growth factor binding protein 3

Anti-IGFBP-3 Antibody-HRP (4I145) 是一种 HRP-conjugated Rabbit 抗体，靶向 IGFBP-3。Anti-IGFBP-3 Antibody-HRP (4I145) 可用于 ELISA。

规格价格库存数量
100 μg
¥ 3,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-IGFBP-3 Antibody-HRP (4I145) is a HRP-conjugated Rabbit antibody targeting IGFBP-3. Anti-IGFBP-3 Antibody-HRP (4I145) can be used in ELISA.
别名insulin-like growth factor binding protein 3
Ig Type
Rabbit IgG
克隆号
4I145
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 0.1-1 μg/ml
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human IGFBP3 (rh IGFBP3; TMPY-00835; Gly28-Lys 291; NP_000589.2), and conjugated with horseradish-peroxidase (HRP).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.
偶联与修饰
偶联
HRP
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human IGFBP3 Protein (TMPY-00835)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight.
运输方式Shipping with blue ice.

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