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顶部生物活性储存和溶解信息计算器

Anti-IGF2R Domain 1-3 Antibody (3T816)

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Anti-IGF2R Domain 1-3 Antibody (3T816)
产品编号 TMAC-02441
别名 MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222

Anti-IGF2R Domain 1-3 Antibody (3T816) 是一种 Rabbit 抗体，靶向 IGF2R Domain 1-3。Anti-IGF2R Domain 1-3 Antibody (3T816) 可用于 WB,ICC/IF,IHC,IP,FCM。

Anti-IGF2R Domain 1-3 Antibody (3T816)

Anti-IGF2R Domain 1-3 Antibody (3T816)

Rating icon 还可以
Anti-IGF2R Domain 1-3 Antibody (3T816)
产品编号 TMAC-02441 别名 MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222

Anti-IGF2R Domain 1-3 Antibody (3T816) 是一种 Rabbit 抗体，靶向 IGF2R Domain 1-3。Anti-IGF2R Domain 1-3 Antibody (3T816) 可用于 WB,ICC/IF,IHC,IP,FCM。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-IGF2R Domain 1-3 Antibody (3T816) is a Rabbit antibody targeting IGF2R Domain 1-3. Anti-IGF2R Domain 1-3 Antibody (3T816) can be used in WB,ICC/IF,IHC,IP,FCM.
别名MPRI, MPR 300, M6PR, M6P/IGF2R, IGF-II receptor, CI-MPR, CD222
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of M6PR on different cell lysates using anti-M6PR antibody at 1/1,000 dilution. Positive control: Lane 1: HepG2, Lane 2: SW480.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-M6PR antibody. Counter stained with hematoxylin.
3. ICC staining M6PR in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining M6PR in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining M6PR in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Flow cytometric analysis of Hela cells with M6PR antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IHC
IP
FCM
推荐剂量
WB: 1:1000-10000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF??1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P11717
化学信息
分子量Theoretical: 274 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

MPR-300MPR300CD-222CD 222

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