Anti-IDUA Polyclonal Antibody is a Rabbit antibody targeting IDUA. Anti-IDUA Polyclonal Antibody can be used in WB,ELISA.

IgG

Human,Mouse

WB: 1:500-2000; ELISA: 1:5000-10000

Polyclonal

KLH conjugated synthetic peptide: human IDUA

Human

IDUA

alpha-L-iduronidase

IDUA is an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Defects in IDUA are the cause of mucopolysaccharidosis type 1H (MPS1H) also known as Hurler syndrome, mucopolysaccharidosis type 1H/S (MPS1H/S) also known as Hurler-Scheie syndrome and mucopolysaccharidosis type 1S (MPS1S) also known as Scheie syndrome. MPS1S is a mild form whilst MPS1H is a severe form of this rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate.