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Anti-HLA-DRA Antibody (9X138)

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Anti-HLA-DRA Antibody (9X138)
产品编号 TMAC-01976
别名 MHC class II antigen DRA, HLA-DRA1, HLA-DRA, HLA class II histocompatibility antigen, DR alpha chain, DR alpha chain

Anti-HLA-DRA Antibody (9X138) 是一种 Rabbit 抗体，靶向 HLA-DRA。Anti-HLA-DRA Antibody (9X138) 可用于 WB,ICC/IF,IHC,FCM。

Anti-HLA-DRA Antibody (9X138)

Anti-HLA-DRA Antibody (9X138)

Rating icon 还可以
Anti-HLA-DRA Antibody (9X138)
产品编号 TMAC-01976 别名 MHC class II antigen DRA, HLA-DRA1, HLA-DRA, HLA class II histocompatibility antigen, DR alpha chain, DR alpha chain

Anti-HLA-DRA Antibody (9X138) 是一种 Rabbit 抗体，靶向 HLA-DRA。Anti-HLA-DRA Antibody (9X138) 可用于 WB,ICC/IF,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-HLA-DRA Antibody (9X138) is a Rabbit antibody targeting HLA-DRA. Anti-HLA-DRA Antibody (9X138) can be used in WB,ICC/IF,IHC,FCM.
别名MHC class II antigen DRA, HLA-DRA1, HLA-DRA, HLA class II histocompatibility antigen, DR alpha chain, DR alpha chain
Ig Type
IgG
交叉反应
Human,Rat
验证活性
1. Western blot analysis of HLA-DR on Daudi cells lysates using anti-HLA-DR antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-HLA-DR antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HLA-DR antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-HLA-DR antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-HLA-DR antibody. Counter stained with hematoxylin.
6. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-HLA-DR antibody. Counter stained with hematoxylin.
7. ICC staining HLA-DR in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining HLA-DR in B16-F1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. Flow cytometric analysis of Jurkat cells with HLA-DR antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IHC
FCM
推荐剂量
WB: 1:1000-5000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P01903
化学信息
分子量Theoretical: 29 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

HLA-DRA 1HLA class II histocompatibility antigen, DR α chainHLA class II histocompatibility antigen, DR a chainDRα chainDR α chainDR a chain

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