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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GSDMA Polyclonal Antibody

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货号 TMAB-06810

Anti-GSDMA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GSDMA。Anti-GSDMA Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-GSDMA Polyclonal Antibody

Anti-GSDMA Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06810

Anti-GSDMA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GSDMA。Anti-GSDMA Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-GSDMA Polyclonal Antibody is a Rabbit antibody targeting GSDMA. Anti-GSDMA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, perinuclear region
组织特异性Expressed predominantly in the gastrointestinal tract and in the skin at a lower level. Also detected in mammary gland. Detected in mucus-secreting pit cells of the gastric epithelium. Not expressed in gastric cancer cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Gasdermin is a 445 amino acid protein that localizes to the perinuclear region of the cytoplasm and belongs to the gasdermin family. Expressed predominately in tissues of the gastrointestinal tract and also present in skin and mammary gland, gasdermin functions to induce apoptosis and is thought to possess tumor suppression activity, specifically in gastric cancer cells. The gene encoding gasdermin maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GSDMA
抗原种属
Human
基因名称
GSDMA
基因ID
284110
蛋白名称
Gasdermin-A
Uniprot ID
Q96QA5
功能
GSDMA induces apoptosis.
化学信息
分子量Theoretical: 49 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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