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Anti-GPRC5D Antibody (8B50) 是一种 Mouse 抗体,靶向 GPRC5D。Anti-GPRC5D Antibody (8B50) 可用于 ELISA,FCM。
Anti-GPRC5D Antibody (8B50) 是一种 Mouse 抗体,靶向 GPRC5D。Anti-GPRC5D Antibody (8B50) 可用于 ELISA,FCM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 μL | ¥ 1,684 | 5日内发货 |
产品描述 | Anti-GPRC5D Antibody (8B50) is a Mouse antibody targeting GPRC5D. Anti-GPRC5D Antibody (8B50) can be used in ELISA,FCM. |
别名 | GPRC5D |
Ig Type | Monoclonal Mouse IgG2b |
克隆号 | 8B50 |
交叉反应 | Human |
验证活性 | 1. Flow cytometric analysis of Human GPRC5D expression on CHO-K1-transfected Cells were stained with purified anti-Human GPRC5D, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. 2. Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D-VLP protein at 5 μg/mL (100 μL/well) can bind GPRC5D Antibody, Mouse MAb, the EC50is 0.5-5 ng/mL. The VLP isotype control Protein is the negative control. |
应用 | ELISA,FCM |
推荐剂量 | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GPRC5D. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells. |
偶联 | Unconjugated |
其他可选修饰符 | APC/FITC/PE |
可提供抗体种类 | 4 |
免疫原 | Recombinant Human GPRC5D Protein |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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