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Anti-gp130/IL6ST Antibody-APC (7J799) 是一种 APC-conjugated Rabbit 抗体,靶向 gp130/IL6ST。Anti-gp130/IL6ST Antibody-APC (7J799) 可用于 FCM。
Anti-gp130/IL6ST Antibody-APC (7J799) 是一种 APC-conjugated Rabbit 抗体,靶向 gp130/IL6ST。Anti-gp130/IL6ST Antibody-APC (7J799) 可用于 FCM。
产品描述 | Anti-gp130/IL6ST Antibody-APC (7J799) is a APC-conjugated Rabbit antibody targeting gp130/IL6ST. Anti-gp130/IL6ST Antibody-APC (7J799) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 7J799 |
交叉反应 | Mouse |
验证活性 | Flow cytometric analysis of Mouse IL6ST(CD130) expression on BABL/c splenocytes. Cells were stained with APC-conjugated anti-Mouse IL6ST(CD130). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
应用 | FCM |
推荐剂量 | 5 μl/Test, 0.1 mg/ml |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL6ST/gp130/CD130 (rM IL6ST/gp130/CD130; TMPY-01832; NP_034690.3; Met1-Glu617) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
研究背景 | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
偶联 | APC |
其他可选修饰符 | Unconjugated/PE |
可提供抗体种类 | 3 |
免疫原 | Recombinant Mouse IL6ST/gp130/CD130 Protein (TMPY-01832) |
抗原种属 | Mouse |
储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
运输方式 | Shipping with blue ice. |
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