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Anti-GAB1 Antibody (4I330)
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产品编号 TMAC-01582
别名 Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1
Anti-GAB1 Antibody (4I330) 是一种 Rabbit 抗体，靶向 GAB1。Anti-GAB1 Antibody (4I330) 可用于 WB,ICC,IF,IHC,FCM。
Anti-GAB1 Antibody (4I330)
Anti-GAB1 Antibody (4I330)
还可以产品编号 TMAC-01582 别名 Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1
Anti-GAB1 Antibody (4I330) 是一种 Rabbit 抗体，靶向 GAB1。Anti-GAB1 Antibody (4I330) 可用于 WB,ICC,IF,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-GAB1 Antibody (4I330) is a Rabbit antibody targeting GAB1. Anti-GAB1 Antibody (4I330) can be used in WB,ICC,IF,IHC,FCM. |
| 别名 | Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of GAB1 on human small intestine tissue lysate using anti-GAB1 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-GAB1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-GAB1 antibody. Counter stained with hematoxylin. 4. ICC staining GAB1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining GAB1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining GAB1 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Hela cells with GAB1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 77 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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