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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ELAVL2+ELAVL4 Polyclonal Antibody

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货号 TMAB-05533

Anti-ELAVL2+ELAVL4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ELAVL2+ELAVL4。Anti-ELAVL2+ELAVL4 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-ELAVL2+ELAVL4 Polyclonal Antibody

Anti-ELAVL2+ELAVL4 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05533

Anti-ELAVL2+ELAVL4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ELAVL2+ELAVL4。Anti-ELAVL2+ELAVL4 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-ELAVL2+ELAVL4 Polyclonal Antibody is a Rabbit antibody targeting ELAVL2+ELAVL4. Anti-ELAVL2+ELAVL4 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Chicken,Dog,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Interacts with IGF2BP1.
组织特异性Brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ELAVL2
抗原种属
Human
基因名称
ELAVL4
基因ID
1996
蛋白名称
ELAV-like protein 4
Uniprot ID
P26378.2
功能
May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.
化学信息
分子量Theoretical: 39+42 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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