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Anti-DPP4/CD26 Antibody-FITC (6M894)

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产品编号 TMAY-01062F

别名 dipeptidylpeptidase 4

Anti-DPP4/CD26 Antibody-FITC (6M894) 是一种 FITC-conjugated Mouse 抗体，靶向 DPP4/CD26。Anti-DPP4/CD26 Antibody-FITC (6M894) 可用于 FCM。

Anti-DPP4/CD26 Antibody-FITC (6M894)

Anti-DPP4/CD26 Antibody-FITC (6M894)

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产品编号 TMAY-01062F 别名 dipeptidylpeptidase 4

Anti-DPP4/CD26 Antibody-FITC (6M894) 是一种 FITC-conjugated Mouse 抗体，靶向 DPP4/CD26。Anti-DPP4/CD26 Antibody-FITC (6M894) 可用于 FCM。

规格价格库存数量
25 T
¥ 685
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100 T
¥ 1,490
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产品介绍

生物活性
产品描述
Anti-DPP4/CD26 Antibody-FITC (6M894) is a FITC-conjugated Mouse antibody targeting DPP4/CD26. Anti-DPP4/CD26 Antibody-FITC (6M894) can be used in FCM.
别名dipeptidylpeptidase 4
Ig Type
Mouse IgG1
克隆号
6M894
交叉反应
Human
特异性
Human DPP-4/CD26/DPPIV
验证活性
Flow cytometric analysis of Human CD26(DPP4) expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD26(DPP4). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
应用FCM
推荐剂量
10 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DPP4 / CD26 (rh DPP4 / CD26; TMPY-00779; NP_001926.2; Asn29-Pro766) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.03%ProClin300
研究背景Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
偶联与修饰
偶联
FITC
其他可选修饰符
Unconjugated/APC/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human DPP4 / CD26 protein (TMPY-00779)
抗原种属
Human
研究领域
Serine Proteases and Regulators
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
运输方式Shipping with blue ice.

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